Richardson Barbra A, Mbori-Ngacha Dorothy, Lavreys Ludo, John-Stewart Grace C, Nduati Ruth, Panteleeff Dana D, Emery Sandra, Kreiss Joan K, Overbaugh Julie
Department of Biostatistics, University of Washington and Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, 98104, USA.
J Virol. 2003 Jun;77(12):7120-3. doi: 10.1128/jvi.77.12.7120-7123.2003.
Steady-state levels of human immunodeficiency virus type 1 (HIV-1) RNA in plasma reached at approximately 4 months postinfection are highly predictive of disease progression. Several studies have investigated viral levels in adults or infants during primary and early infection. However, no studies have directly compared these groups. We compared differences in peak and set point plasma HIV-1 RNA viral loads among antiretrovirus-naive Kenyan infants and adults for whom the timing of infection was well defined. Peak and set point viral loads were significantly higher in infants than in adults. We did not observe any gender-specific differences in viral set point in either adults or infants. However, infants who acquired HIV-1 in the first 2 months of life, either in utero, intrapartum, or through early breast milk transmission, had significantly higher set point HIV-1 RNA levels than infants who were infected after 2 months of age through late breast milk transmission or adults who were infected through heterosexual transmission.
感染后约4个月时血浆中人类免疫缺陷病毒1型（HIV-1）RNA的稳态水平可高度预测疾病进展。多项研究调查了成人或婴儿在初次感染和早期感染期间的病毒水平。然而，尚无研究直接比较这些群体。我们比较了感染时间明确的未接受抗逆转录病毒治疗的肯尼亚婴儿和成人之间血浆HIV-1 RNA病毒载量的峰值和平台期的差异。婴儿的病毒载量峰值和平台期显著高于成人。我们未观察到成人或婴儿的病毒平台期存在任何性别特异性差异。然而，在出生后头2个月内通过宫内、分娩期间或早期母乳传播感染HIV-1的婴儿，其HIV-1 RNA平台期水平显著高于2个月龄后通过晚期母乳传播感染的婴儿或通过异性传播感染的成人。
