Hoogkamp-Korstanje J A
Academisch Ziekenhuis, afd. Medische Microbiologie, Nijmegen.
Ned Tijdschr Geneeskd. 1999 Jun 19;143(25):1293-5.
The committee 'Growth promoting antimicrobials' of the Health Council of the Netherlands in 1998 advised immediate prohibition of all growth promoting antimicrobials related to human drugs and decrease of use of other growth promoting antimicrobials during the next three years in Europe. It is clear that frequent use of antibiotics is associated with development of resistance by selection in animals (and man), but it is not proven that this is an explanation of resistance in the human community. We know only little about the mechanisms and conditions of transfer of bacteria to man. Other questions raised are: what about the resulting possible increase of therapeutic application of antibiotics in animals, how to handle the increase of dung, nitrogen and phosphate in the environment and how farmers can survive with a decrease in income, sometimes by as much as 50%? Although many will feel sympathy for the report and its recommendations, implementing them will be difficult and possibly premature.
1998年，荷兰卫生委员会的“促生长抗菌药物”委员会建议立即禁止所有与人类药物相关的促生长抗菌药物，并在未来三年内减少欧洲其他促生长抗菌药物的使用。很明显，频繁使用抗生素与动物（和人类）中通过选择产生耐药性有关，但尚未证明这是人类群体中耐药性的一种解释。我们对细菌传播给人类的机制和条件知之甚少。提出的其他问题包括：动物抗生素治疗应用可能增加的情况如何，如何处理环境中粪便、氮和磷的增加，以及农民在收入有时减少多达50%的情况下如何生存？尽管许多人会对该报告及其建议表示赞同，但实施起来将很困难，而且可能为时过早。
