Graham S L, Klistorner A, Grigg J R, Billson F A
Save Sight Institute, Department of Ophthalmology, Sydney University, NSW, Australia.
Surv Ophthalmol. 1999 Jun;43 Suppl 1:S199-209. doi: 10.1016/s0039-6257(99)00011-9.
The introduction of multifocal stimulus recording has enhanced our ability to examine the human visual field with electrophysiologic techniques. We have adapted the multifocal pattern visual evoked potential (PVEP) to detect visual field loss. In glaucoma patients we sought to determine the extent to which the PVEP amplitudes correlate with perimetric thresholds. Multifocal pseudorandomly alternated pattern stimuli, which were cortically scaled in size, were presented with use of the VERIS-Scientific system. Bipolar occipital straddle electrode positions were used. The visual field up to 25 degrees of eccentricity was investigated. Forty-three glaucoma patients with reproducible visual field defects were tested. The bipolar PVEP corresponded well with Humphrey visual field defects, showing loss of signal in the scotoma area. For Humphrey quadrant threshold totals and PVEP quadrant amplitudes, the correlation coefficient was strong (r = 0.49, P < 0.0001). The multifocal PVEP demonstrates good correspondence with the topography of the visual field. This technique represents the first practical application of the multifocal PVEP to objective detection of visual field defects in glaucoma.
多焦点刺激记录技术的引入提高了我们运用电生理技术检测人类视野的能力。我们采用多焦点图形视觉诱发电位（PVEP）来检测视野缺损。在青光眼患者中，我们试图确定PVEP振幅与视野阈值的相关程度。使用VERIS - Scientific系统呈现经皮质大小缩放的多焦点伪随机交替图形刺激。采用双极枕部跨电极位置。研究了偏心度达25度的视野。对43例具有可重复性视野缺损的青光眼患者进行了检测。双极PVEP与汉弗莱视野缺损情况吻合良好，在暗点区域显示信号缺失。对于汉弗莱象限阈值总和与PVEP象限振幅，相关系数很强（r = 0.49，P < 0.0001）。多焦点PVEP与视野地形图显示出良好的对应关系。该技术代表了多焦点PVEP在客观检测青光眼视野缺损方面的首次实际应用。
