Klistorner A I, Graham S L, Martins A
Save Sight Institute, Department of Ophthalmology, Sydney University, Australia.
Doc Ophthalmol. 2000;100(2-3):155-65. doi: 10.1023/a:1002772520539.
To determine if a multifocal PERG could be recorded in normals, and to examine changes in the multifocal PERG in glaucoma patients. To compare the ability of multifocal PERG and multifocal VEP responses in the same individuals to identify localised field defects in glaucoma.
Using the VERIS Scientific system multifocal PERGs were recorded from 19 sites of the visual field according to pseudo-random binary m-sequence. Twenty normals and 15 glaucoma subjects were tested. Multifocal pattern VEPs were also recorded in the glaucoma cases using a cortically scaled stimulus.
The second order kernel of the PERG shows a consistent signal. The overall PERG amplitude decreases with age in normals. In glaucoma the PERG amplitude was reduced across the field, but reductions did not correspond to the area of the scotoma. The VEP showed localised signal reductions in all 15 cases of glaucoma.
A multifocal PERG can be recorded in normals. However it did not reflect localised ganglion cell losses, whereas the multifocal pattern VEP recorded to a very similar stimulus in the same individual did show losses in the scotoma area.
确定正常个体是否可记录到多焦图形视网膜电图（PERG），并检查青光眼患者多焦PERG的变化。比较同一受试者多焦PERG和多焦视觉诱发电位（VEP）识别青光眼局部视野缺损的能力。
使用VERIS Scientific系统，根据伪随机二进制m序列从视野的19个部位记录多焦PERG。测试了20名正常人和15名青光眼患者。还使用皮层缩放刺激在青光眼患者中记录多焦图形VEP。
PERG的二阶核显示出一致的信号。正常个体中，PERG的总体振幅随年龄降低。青光眼患者中，整个视野的PERG振幅均降低，但降低程度与暗点区域不对应。所有15例青光眼患者的VEP均显示局部信号降低。
正常个体可记录到多焦PERG。然而，它并未反映局部神经节细胞丢失，而在同一受试者中记录到的、刺激非常相似的多焦图形VEP确实显示暗点区域存在丢失。
