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一种来自蓝花楹的具有脂氧合酶抑制活性的新型酚类脂肪酸酯。

A new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia.

作者信息

Ali R M, Houghton P J

出版信息

Planta Med. 1999 Jun;65(5):455-7. doi: 10.1055/s-2006-960811.

DOI:10.1055/s-2006-960811
PMID:10418336
Abstract

The dichloromethane extract of the stem of jacaranda filicifolia Don. showed inhibitory activity in vitro against soybean 5-lipoxygenase. Systematic fractionation to isolate the compounds responsible resulted in the isolation of three active compounds, 2 alpha, 3 alpha-dihydroxyurs-12-en-28-oic acid, beta-sitosterol, and one of which was new which was characterised as 2-(4-hydroxyphenyl)ethyl 1-dodecyloctadecanoate. This type of compound has not previously been reported to inhibit lipoxygenase.

摘要

蓝花楹(Jacaranda filicifolia Don.)茎的二氯甲烷提取物在体外对大豆5-脂氧合酶表现出抑制活性。通过系统分级分离以分离出起作用的化合物,结果分离出三种活性化合物,2α,3α-二羟基乌苏-12-烯-28-酸、β-谷甾醇,其中一种是新化合物,其被鉴定为2-(4-羟基苯基)乙基1-十二烷基十八烷酸酯。此前尚未报道过此类化合物具有抑制脂氧合酶的作用。

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