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来自伏地筋骨草的一种硬脂酸衍生物的抗菌活性。

Antibacterial activity of a stearic acid derivative from Stemodia foliosa.

作者信息

Dantas da Silva Lourinalda Luiza, Nascimento Márcia, Siqueira Silva Dulce Helena, Furlan Maysa, da Silva Bolzani Vanderlan

机构信息

Departamento de Antibióticos - Centro de Ciências Biológicas, Universidade Federal de Pernambuco, PE, Brazil.

出版信息

Planta Med. 2002 Dec;68(12):1137-9. doi: 10.1055/s-2002-36346.

DOI:10.1055/s-2002-36346
PMID:12494347
Abstract

From the hexane-soluble fraction of an ethanol extract from leaves and stems of Stemodia foliosa (Scrophulariaceae), the new stearic acid 4-[(n-pentoxy)phenethyl] ester (1) was isolated. This compound exhibited antibacterial properties at 10 microg/mL concentration by using disc diffusion method against Gram-positive bacteria Bacillus cereus and Bacillus subtilis and fast-acid bacterium Mycobacterium fortuitum. The structure of the new compound was elucidated by spectroscopic methods and by chemical conversion.

摘要

从绵毛茎叶草(玄参科)叶和茎的乙醇提取物的正己烷可溶部分中,分离出了新的硬脂酸4-(正戊氧基)苯乙酯。采用纸片扩散法,该化合物在浓度为10微克/毫升时,对革兰氏阳性菌蜡样芽孢杆菌和枯草芽孢杆菌以及快速生长型分枝杆菌偶然分枝杆菌表现出抗菌特性。通过光谱方法和化学转化对新化合物的结构进行了阐明。

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