Morinaka S, Sato T, Miyoshi H, Iwashita K
Department of Otorhinolaryngology, Kobe Teishin Hospital, Kobe, Japan.
Auris Nasus Larynx. 1999 Jul;26(3):349-53. doi: 10.1016/s0385-8146(99)00007-3.
Multiple symmetrical lipomatosis (Madelung's disease) is a rare disease with multiple symmetrical unencapsulated fatty accumulation diffusely involving the neck, the shoulders and the upper extremities (Kohan et al. Otolaryngol. Head Neck Surg. 1993;108:156-159). We describe a 48-year-old Japanese man with a history of alcoholism and liver cirrhosis who reported gradually enlarging masses in his cervical region for 4 years. MRI revealed large masses suggesting lipomas in the neck. The patient underwent a two-stage lipectomy. This patient is the 13th case reported in Japan since 1978, though over 200 cases have been reported since 1846 in Europe, most of them from the Mediterranean (Kitano et al. ORL 1994;56:177 180; Kaku et al. Endocrinol. Diabetol. 1997;4:103-106).
多发性对称性脂肪瘤病（马德隆病）是一种罕见疾病，表现为多个对称性、无包膜的脂肪堆积，广泛累及颈部、肩部和上肢（科汉等人，《耳鼻喉科头颈外科》，1993年；108:156 - 159）。我们报告一例48岁的日本男性，有酗酒和肝硬化病史，自述颈部肿物逐渐增大4年。磁共振成像（MRI）显示颈部有提示脂肪瘤的巨大肿物。该患者接受了两期脂肪切除术。此患者是日本自1978年以来报告的第13例病例，而自1846年以来欧洲已报告200多例，其中大多数来自地中海地区（北野等人，《耳鼻喉科文献》，1994年；56:177 - 180；加库等人，《内分泌与糖尿病》，1997年；4:103 - 106）。
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