Narvskaia O V, Mokrousov I V, Otten T F, Vishnevskiĭ B I
Probl Tuberk. 1999(3):39-41.
RFLP analysis using a IS6110 probe was used to genetically marked polyresistant Mycobacterium tuberculosis strains isolated from patients with pulmonary tuberculosis in the north-west of Russia in 1996-1997. Two groups of genetically closely related, but epidemiologically unrelated strains of different territorial origin were identified. The epidemiological value of and the origin of genetically identified and related strains are discussed. The significance and prospects of the use of RFLP-based genome dactyloscopy are shown for follow-ups of the circulation of epidemic strains in order to improve the system of tuberculosis epidemiological surveillance and treatment efficiency control.
1996 - 1997年，采用IS6110探针的限制性片段长度多态性（RFLP）分析对从俄罗斯西北部肺结核患者中分离出的耐多药结核分枝杆菌菌株进行基因标记。鉴定出两组遗传关系密切但流行病学上无关的不同地域来源的菌株。讨论了基因鉴定的相关菌株的流行病学价值及其起源。展示了基于RFLP的基因组指纹图谱在追踪流行菌株传播方面的意义和前景，以便改进结核病流行病学监测系统和治疗效果控制。
