Bulikowski W, Pietrzak I, Borzecki A, Lingas W
Polyclinic of Gniezno Tannery, Poland.
Magnes Res. 1999 Jun;12(2):115-21.
Investigations were performed over 30 days on 25 male rats Wistar breed divided into five groups. Animals received intraperitoneally (i.p.) potassium dichromate (KDCH) 5 mg/kg (basal doses, b.d.), 2 mg/kg (0.4 b.d.) and 100 mg Mg Cl2/kg body weight (b.w.). In performed investigations the highest concentration of chromium in animal skin 1.17 +/- 0.11 micrograms/g was observed by i.p. administration of KDCH 5 mg/kg b.w. Simultaneous i.p. administration of KDCH 5 mg/kg b.w. and MgCl2 100 mg/kg b.w. resulted in significant lower concentration of chromium (in comparison to the preceding group) in animal skin: 0.8 +/- 0.2 microgram/g (p < 0.001). In i.p. administration of KDCH in the doses of 0.4 b.d. the concentration of Cr in the skin amounted to 0.55 +/- 0.1 microgram/g. Values of Cr in the skin in exposed groups were significantly higher than in the control group, (p < 0.001).
对25只雄性Wistar品系大鼠进行了为期30天的研究，这些大鼠被分为五组。动物腹腔注射（i.p.）重铬酸钾（KDCH）5毫克/千克（基础剂量，b.d.）、2毫克/千克（0.4 b.d.）以及100毫克氯化镁/千克体重（b.w.）。在进行的研究中，腹腔注射5毫克/千克体重的KDCH时，动物皮肤中铬的最高浓度为1.17±0.11微克/克。同时腹腔注射5毫克/千克体重的KDCH和100毫克/千克体重的氯化镁，导致动物皮肤中铬的浓度（与前一组相比）显著降低：0.8±0.2微克/克（p<0.001）。腹腔注射0.4 b.d.剂量的KDCH时，皮肤中铬的浓度为0.55±0.1微克/克。暴露组皮肤中的铬含量显著高于对照组（p<0.001）。
