Hu Cai-Yun, Qian Zhen-Zhong, Gong Feng-Feng, Lu Shan-Shan, Feng Fang, Wu Yi-Le, Yang Hui-Yun, Sun Ye-Huan
Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan road, Hefei, 230032, Anhui, China.
J Neural Transm (Vienna). 2015 Feb;122(2):307-20. doi: 10.1007/s00702-014-1261-8. Epub 2014 Jun 18.
Previous studies examining the possible role of the methylenetetrahydrofolate reductase (MTHFR) polymorphisms in the development of schizophrenia (SZ) and bipolar disorder (BPD) have provided inconclusive findings, this meta-analysis was therefore designed to get a more reliable assessment. A total of 38 articles were identified through a search of electronic databases, up to 27 February 2014. Odds ratios (ORs) with 95% confidence interval (CIs) were calculated using random effects models. Meta-analysis showed that MTHFR C677T was significantly associated with SZ, the highest OR was found for the recessive model (for TT vs. CT + CC: OR = 1.34, 95% CI: 1.18-1.53); a marginal association of MTHFR C677T with increased risk of BPD has also been found for the recessive model (OR = 1.26, 95% CI: 1.00-1.59). Subgroup analysis by ethnicity indicated that the significant association with SZ and BPD existed among Asian and African populations, but not for the white. MTHFR A1298C was significant associated with SZ, the highest OR for the dominant model (OR = 1.13, 95% CI: 1.03-1.24). Subgroup analysis indicated a significant association with SZ existed in Asian populations, not among the white populations and no significant association was detected between the MTHFR A1298C and BPD in all groups. We conclude that MTHFR polymorphism is associated with SZ and BPD among Asian, African populations, but not the white.
以往关于亚甲基四氢叶酸还原酶（MTHFR）基因多态性在精神分裂症（SZ）和双相情感障碍（BPD）发病中可能作用的研究结果尚无定论，因此本荟萃分析旨在获得更可靠的评估。通过检索电子数据库，截至2014年2月27日，共识别出38篇文章。采用随机效应模型计算比值比（OR）及95%置信区间（CI）。荟萃分析显示，MTHFR C677T与SZ显著相关，隐性模型的OR最高（TT vs. CT + CC：OR = 1.34，95% CI：1.18 - 1.53）；对于隐性模型，也发现MTHFR C677T与BPD风险增加存在边缘关联（OR = 1.26，95% CI：1.00 - 1.59）。按种族进行的亚组分析表明，亚洲和非洲人群中存在与SZ和BPD的显著关联，而白种人群中不存在。MTHFR A1298C与SZ显著相关，显性模型的OR最高（OR = 1.13，95% CI：1.03 - 1.24）。亚组分析表明，亚洲人群中存在与SZ的显著关联，白种人群中不存在，且在所有组中均未检测到MTHFR A1298C与BPD之间存在显著关联。我们得出结论，MTHFR基因多态性在亚洲、非洲人群中与SZ和BPD相关，但在白种人群中不相关。
