Tammiala-Salonen T, Forssell H
Institute of Dentistry, Turku University, Finland.
J Orofac Pain. 1999 Spring;13(2):83-8.
An 8-week parallel, placebo-controlled, double-blind trial evaluated the efficacy of the antidepressant trazodone in the treatment of chronic burning mouth pain.
Thirty-seven carefully selected women aged 39 to 71 (mean 58.6 years) were randomized to receive either 200 mg of trazodone or a placebo in a similar manner. Pain and pain-related symptoms were evaluated on a visual analogue scale and other measures at 0, 2, 4, and 8 weeks.
There were no significant differences between the groups in treatment effects for pain or pain-related symptoms. Seven patients in the trazodone group and 2 in the placebo group failed to complete the trial because of side effects. The most common side effects were dizziness and drowsiness.
In this controlled trial, trazodone failed to relieve burning mouth pain.
一项为期8周的平行、安慰剂对照、双盲试验评估了抗抑郁药曲唑酮治疗慢性灼口痛的疗效。
37名精心挑选的39至71岁女性（平均58.6岁）被随机分组，分别以类似方式接受200毫克曲唑酮或安慰剂治疗。在第0、2、4和8周时，通过视觉模拟量表和其他测量方法对疼痛及与疼痛相关的症状进行评估。
两组在疼痛或与疼痛相关症状的治疗效果上无显著差异。曲唑酮组有7名患者，安慰剂组有2名患者因副作用未完成试验。最常见的副作用是头晕和嗜睡。
在这项对照试验中，曲唑酮未能缓解灼口痛。
