Goodkin K, Gullion C M, Agras W S
Department of Psychiatry, Stanford University Medical Center, California 33101.
J Clin Psychopharmacol. 1990 Aug;10(4):269-78.
A 6-week placebo-controlled trial evaluated the efficacy of trazodone hydrochloride for the relief of chronic low back pain. Forty-two subjects (22 trazodone, 20 placebo) with a 20.3-year average history of back pain were titrated to an average dose of trazodone 201 mg or placebo 238 mg and evaluated daily on a Visual Analogue Scale of pain intensity, at 2-week intervals on an observer rating of pain behavior while walking, and before and after the trial on the Beck Depression Inventory, the Sickness Impact Profile, and a solid state microcomputer (Vitalog) that measured physical activity. Trazodone blood levels and urine toxicology screens were also obtained. There were no significant differences between groups in treatment effect. The results of this study require confirmation by longer trials with larger, less chronic, more homogeneous samples at higher doses with follow-up assessments.
一项为期6周的安慰剂对照试验评估了盐酸曲唑酮缓解慢性下腰痛的疗效。42名平均有20.3年背痛病史的受试者（22名服用曲唑酮，20名服用安慰剂）被滴定至曲唑酮平均剂量201毫克或安慰剂238毫克，并每天使用视觉模拟疼痛强度量表进行评估，每2周由观察者对行走时的疼痛行为进行评分，在试验前后使用贝克抑郁量表、疾病影响概况量表以及一台测量身体活动的固态微型计算机（Vitalog）进行评估。同时还获取了曲唑酮血药浓度和尿液毒理学筛查结果。两组在治疗效果上没有显著差异。本研究结果需要通过更长时间的试验来证实，试验样本应更大、病程更短、更具同质性，使用更高剂量并进行随访评估。
