Watanabe H, Miyashita Y, Murano T, Hiroh Y, Itoh Y, Shirai K
Department of Clinical Laboratory Medicine, Sakura Hospital, School of Medicine, Toho University, Chiba, Japan.
Atherosclerosis. 1999 Jul;145(1):45-50. doi: 10.1016/s0021-9150(99)00012-x.
To clarify the factors regulating preheparin serum lipoprotein lipase mass (preheparin LPL mass), the correlations between preheparin LPL mass and age, gender and types of hyperlipidemias were investigated in 377 persons who underwent annual health examinations. Preheparin LPL mass level did not significantly differ in individuals from 19 to 70 years old, for both men and women. Preheparin LPL mass level correlated negatively with triglyceride (TG), positively with high density lipoprotein-cholesterol (HDL-C), and not at all with total cholesterol (TC) or low density lipoprotein-cholesterol (LDL-C). Preheparin LPL mass levels were apparently higher in women than in men, but when serum lipid levels were adjusted, preheparin LPL mass levels were identical. In type IV and IIb hyperlipidemia, preheparin LPL mass levels were lower than in type IIa patients and in normals. Remnant positive individuals had lower levels of preheparin LPL mass than the negative individuals. In conclusion, preheparin LPL mass levels were not affected by aging and gender, but were lower in the conditions in which TG catabolism was disturbed, indicating that preheparin LPL mass might reflect somewhat the amount of LPL working in the body.
为阐明调节肝素前血清脂蛋白脂肪酶质量（肝素前LPL质量）的因素，我们对377名接受年度健康检查的人员进行了研究，调查了肝素前LPL质量与年龄、性别及高脂血症类型之间的相关性。19至70岁的男性和女性个体，其肝素前LPL质量水平无显著差异。肝素前LPL质量水平与甘油三酯（TG）呈负相关，与高密度脂蛋白胆固醇（HDL-C）呈正相关，与总胆固醇（TC）或低密度脂蛋白胆固醇（LDL-C）无相关性。女性的肝素前LPL质量水平明显高于男性，但调整血脂水平后，肝素前LPL质量水平相同。在IV型和IIb型高脂血症中，肝素前LPL质量水平低于IIa型患者和正常人。残粒阳性个体的肝素前LPL质量水平低于阴性个体。总之，肝素前LPL质量水平不受年龄和性别的影响，但在TG分解代谢受干扰的情况下较低，这表明肝素前LPL质量可能在一定程度上反映了体内发挥作用的LPL的量。
