Mohammadi Keyhan, Alizadeh Sani Mahmood, Nattagh-Eshtivani Elyas, Yaribash Shakila, Rahmani Jamal, Shokrollahi Yancheshmeh Behdad, Julian McClements David
Department of Clinical Pharmacy Faculty of Pharmacy Tehran University of Medical Sciences Tehran Iran.
Division of Food Safety and Hygiene School of Public Health Tehran University of Medical Sciences Tehran Iran.
Food Sci Nutr. 2021 Jun 21;9(8):4629-4638. doi: 10.1002/fsn3.2416. eCollection 2021 Aug.
Polyphenolic and flavonoid compounds are claimed to improve blood lipid profiles and to provide protective effects against cardiovascular disease. For this reason, we conducted a systematic review and meta-analysis of studies that comprehensively investigated the effects of cornelian cherry supplementation on lipid profiles in rat models. Up to December 2020, 855 articles were screened, and finally, seven articles were selected as eligible for the meta-analysis. This meta-analysis revealed that cornelian cherry supplementation significantly decreased low-density lipoprotein (LDL) (WMD = -6.38 mg/dl; 95% CI, -9.93 to-2.84; < .001), triglyceride (TG) (WMD = -52.36 mg/dl; 95% CI, -80.50 to -24.22; < .005), and cholesterol level (WMD = -37.16 mg/dl; 95% CI, -51.19 to -23.13; < .005) in treated rats compared with control groups. A nonsignificant increase in high-density lipoprotein (HDL) level was observed (WMD = 4.21 mg/dl; 95% CI, -3.25 to 11.66; = .268). These results suggest that cherry supplementation may have health effects by modifying lipid profiles. However, there is a need for more well-controlled human clinical trials to make more definitive conclusions about the potential health benefits of cherry supplementation.
多酚和黄酮类化合物据称可改善血脂状况，并对心血管疾病起到保护作用。因此，我们对全面研究山茱萸补充剂对大鼠模型血脂状况影响的研究进行了系统评价和荟萃分析。截至2020年12月，共筛选了855篇文章，最终选择了7篇文章作为荟萃分析的合格文章。该荟萃分析表明，与对照组相比，补充山茱萸可使受试大鼠的低密度脂蛋白（LDL）显著降低（加权均数差[WMD]=-6.38mg/dl；95%置信区间[CI]，-9.93至-2.84；P<0.001）、甘油三酯（TG）显著降低（WMD=-52.36mg/dl；95%CI，-80.50至-24.22；P<0.005）以及胆固醇水平显著降低（WMD=-37.16mg/dl；95%CI，-51.19至-23.13；P<0.005）。观察到高密度脂蛋白（HDL）水平有不显著的升高（WMD=4.21mg/dl；95%CI，-3.25至11.66；P=0.268）。这些结果表明，补充山茱萸可能通过改变血脂状况对健康产生影响。然而，需要进行更多严格对照的人体临床试验，以便就补充山茱萸的潜在健康益处得出更明确的结论。
