Smith G N, Walker M C, McGrath M J
Department of Obstetrics and Gynaecology, University of Toronto, Ontario, Canada.
Br J Obstet Gynaecol. 1999 Jul;106(7):736-9. doi: 10.1111/j.1471-0528.1999.tb08376.x.
Thirty-three women in preterm labour were randomised in a double-blind fashion to receive either transdermal nitroglycerin (n = 17) or placebo (n = 16). Both groups had significant (P < 0.001) change in the cervix prior to randomisation. The primary outcome measure was delivery within 48 hours of randomisation. Fewer women randomised to nitroglycerin treatment (6/17) were delivered within 48 hours, compared with the placebo treatment (10/16) (RR 0.56, 95% CI 0.27 to 1.19). This pilot study lends support to two case series published that suggest that transdermal nitroglycerin may be promising as a safe, effective means for tocolysis.
33名早产女性被随机分为两组，采用双盲法，一组接受经皮硝酸甘油治疗（n = 17），另一组接受安慰剂治疗（n = 16）。随机分组前两组宫颈均有显著变化（P < 0.001）。主要观察指标为随机分组后48小时内分娩。与安慰剂组（10/16）相比，接受硝酸甘油治疗的女性在48小时内分娩的较少（6/17）（相对危险度0.56，95%可信区间0.27至1.19）。这项初步研究支持了已发表的两个病例系列研究结果，表明经皮硝酸甘油可能是一种有前景的安全、有效的宫缩抑制方法。
