Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1.
作者信息
Kashuba A D, Dyer J R, Kramer L M, Raasch R H, Eron J J, Cohen M S
机构信息
School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
出版信息
Antimicrob Agents Chemother. 1999 Aug;43(8):1817-26. doi: 10.1128/AAC.43.8.1817.
Abstract
摘要
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Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort Study.对HIV感染进行有效的抗逆转录病毒治疗可抑制精液中HIV的排出。瑞士HIV队列研究。
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Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy.接受高效抗逆转录病毒治疗的男性精液中的1型人类免疫缺陷病毒
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5
Resistance of HIV-1 to antiretroviral agents in blood and seminal plasma: implications for transmission.血液和精液中HIV-1对抗逆转录病毒药物的耐药性：对传播的影响。
AIDS. 1998 Oct 22;12(15):F181-9. doi: 10.1097/00002030-199815000-00003.
6
Sexual transmission of an HIV-1 variant resistant to multiple reverse-transcriptase and protease inhibitors.对多种逆转录酶和蛋白酶抑制剂耐药的HIV-1变异株的性传播。
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7
The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy.在CD4 T细胞计数高的HIV-1感染无症状患者中，未增大的淋巴结是病毒复制和CD4 T细胞增殖的场所。高效抗逆转录病毒疗法的影响。
J Exp Med. 1998 Mar 16;187(6):949-59. doi: 10.1084/jem.187.6.949.
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Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy.强效抗逆转录病毒治疗一年后血液和淋巴结中的人类免疫缺陷病毒复制及基因型耐药性
J Virol. 1998 Mar;72(3):2422-8. doi: 10.1128/JVI.72.3.2422-2428.1998.
9
Rapid, transient changes at the env locus of plasma human immunodeficiency virus type 1 populations during the emergence of protease inhibitor resistance.在蛋白酶抑制剂耐药性出现期间，血浆1型人类免疫缺陷病毒群体env基因座的快速、短暂变化。
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Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood.精液中可培养的1型人类免疫缺陷病毒（HIV-1）与精液及血液中HIV-1 RNA水平之间的关联：HIV-1在精液和血液之间存在区室化的证据
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