Andrology Department and Clinical Andrology Laboratory, Concord Hospital, Concord, NSW, Australia.
ANZAC Research Institute, University of Sydney, Concord, NSW, Australia.
Drug Test Anal. 2022 Sep;14(9):1623-1628. doi: 10.1002/dta.3331. Epub 2022 Jun 9.
The high sensitivity of antidoping detection tests creates the possibility of inadvertent doping due to an athlete's unknowing ingestion of contaminated environmental sources such as dietary supplements, food, or drinks. Recently, athletes denying use of a prohibited substance have claimed that the positive antidoping tests was due to exchange of bodily fluids with a nonathlete partner using a prohibited substance. Measurement of drugs in semen is largely limited to one or very few samples due to the inaccessibility of sufficiently frequent semen samples for detailed pharmacokinetics. An emerging issue in semen drug measurements is that semen samples may contain residual urine from ejaculation left in the urethra; however, the urine content in semen samples has not been studied. In the present study, we employed concurrent creatinine measurements in urine and seminal plasma to determine the urine content of semen samples.
兴奋剂检测的高灵敏度使得运动员因不知情摄入受污染的环境源（如膳食补充剂、食物或饮料）而无意中摄入兴奋剂成为可能。最近，一些否认使用禁用物质的运动员声称，阳性兴奋剂检测结果是由于与使用禁用物质的非运动员伴侣交换了体液。由于无法频繁获得足够的精液样本来进行详细的药代动力学研究，因此精液中药物的测量在很大程度上仅限于一个或很少几个样本。在精液药物测量中出现的一个新问题是，精液样本中可能含有射精后残留在尿道中的尿液；然而，尚未研究精液样本中的尿液含量。在本研究中，我们同时测量尿液和精浆中的肌酐，以确定精液样本中的尿液含量。
