Remarque E J
Section of Gerontology and Geriatrics, Leiden University Medical Centre, The Netherlands.
Exp Gerontol. 1999 Jun;34(3):445-52. doi: 10.1016/s0531-5565(99)00007-8.
Influenza is an important cause of morbidity and mortality in the elderly. Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths, but the antibody induction by influenza vaccines is not always optimal in the elderly. The lower serological efficacy of influenza vaccines that is often observed in the elderly may be due to a multitude of factors. Here we will discuss some of these factors. These include health status and previous exposures to influenza viruses. In addition, we will discuss possibilities to improve antibody responses to influenza vaccination.
流感是老年人发病和死亡的重要原因。流感疫苗已被证明能成功减少与流感和肺炎相关的住院和死亡，但流感疫苗在老年人中诱导产生抗体的效果并不总是最佳的。在老年人中经常观察到的流感疫苗血清学效力较低可能是由于多种因素。在此我们将讨论其中一些因素。这些因素包括健康状况和既往接触流感病毒的情况。此外，我们还将讨论提高对流感疫苗抗体反应的可能性。
