Jin S H, Park J K, Nam K Y, Park S N, Jung N P
Department of Biochemical Pharmacology, Korea Ginseng & Tobacco Research Institute, Taejon, South Korea.
J Ethnopharmacol. 1999 Aug;66(2):123-9. doi: 10.1016/s0378-8741(98)00190-1.
The effects of two ginseng saponins having a different ratio of protopanaxadiol (PD) and protopanaxatriol saponins (PT) on the learning impairment induced by scopolamine, and learning and memory in mice were investigated in a passive avoidance task and a Morris water maze task. The ratio of PD and PT was 1.24 and 1.46, respectively. Before training, the ginseng saponins were administered intraperitoneally at doses of 50 and 100 mg/kg. The two saponins improved the scopolamine-induced learning impairment at different dosages in mice, 50 and 100 mg/kg, respectively. However, the two saponins did not show a favorable effect on learning and memory in normal mice. Korean red ginseng saponin with a low PD/PT ratio had an improving effect on spatial working memory, but the saponin with a high PD/PT ratio did not. This finding suggests that the PD/PT ratio of the ginseng saponins may be an important factor in the pharmacological role of red ginseng as a medicinal herb.
研究了原人参二醇（PD）与人参三醇皂苷（PT）比例不同的两种人参皂苷对东莨菪碱诱导的小鼠学习障碍以及学习和记忆的影响，采用被动回避任务和莫里斯水迷宫任务进行研究。PD与PT的比例分别为1.24和1.46。训练前，人参皂苷分别以50和100mg/kg的剂量腹腔注射。两种皂苷分别在50和100mg/kg的不同剂量下改善了东莨菪碱诱导的小鼠学习障碍。然而，两种皂苷对正常小鼠的学习和记忆没有显示出有益作用。低PD/PT比例的高丽红参皂苷对空间工作记忆有改善作用，但高PD/PT比例的皂苷则没有。这一发现表明，人参皂苷的PD/PT比例可能是红参作为草药发挥药理作用的一个重要因素。
