Araújo Viel T, Diogo Domingos C, da Silva Monteiro A P, Riggio Lima-Landman M T, Lapa A J, Souccar C
Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Pharmacology, Brazil.
J Ethnopharmacol. 1999 Aug;66(2):193-8. doi: 10.1016/s0378-8741(98)00171-8.
The antiurolithiatic activity of the water extract of Costus spiralis Roscoe was tested on formation of calculi on implants of calcium oxalate crystals or zinc disc in the urinary bladder of rats. The plant is a species from the family Zingiberaceae used in Brazilian folk medicine in urinary affections and for expelling urinary stones. Implantation of the foreign body in the urinary bladder of adult rats induced formation of urinary stones and hypertrophy of the smooth musculature. Oral treatment with the extract of Costus spiralis Roscoe (0.25 and 0.5 g/kg per day) after 4 weeks surgery reduced the growth of calculi, but it did not prevent hypertrophy of the organ smooth musculature. The contractile responses of isolated urinary bladder preparations to the muscarinic agonist bethanecol, in the presence and absence of the extract (0.3-3 mg/ml) or atropine (0.3-3 nM) did not differ among the experimental groups. The results indicate that the extract of Costus spiralis Roscoe is endowed with antiurolithiatic activity confirming thus folk information. The effect, however, was unrelated to increased diuresis or to a change of the muscarinic receptor affinity of the bladder smooth musculature to cholinergic ligands.
在大鼠膀胱内植入草酸钙晶体或锌盘以形成结石，以此测试了螺旋闭鞘姜水提取物的抗尿路结石活性。该植物是姜科的一种植物，在巴西民间医学中用于治疗泌尿系统疾病和排出尿路结石。在成年大鼠膀胱内植入异物会导致尿路结石形成和平滑肌组织肥大。手术后4周，口服螺旋闭鞘姜提取物（每天0.25和0.5克/千克）可减少结石生长，但不能防止器官平滑肌组织肥大。在有或没有提取物（0.3 - 3毫克/毫升）或阿托品（0.3 - 3纳摩尔）存在的情况下，分离的膀胱制剂对毒蕈碱激动剂氨甲酰甲胆碱的收缩反应在各实验组之间没有差异。结果表明，螺旋闭鞘姜提取物具有抗尿路结石活性，从而证实了民间说法。然而，这种作用与利尿增加或膀胱平滑肌组织对胆碱能配体的毒蕈碱受体亲和力变化无关。
