新型杀菌剂4,4'-(1,6-己二亚甲基二氧二羰基)双(1-烷基吡啶鎓碘化物)的合成及其抗菌特性

Synthesis and antimicrobial characteristics of novel biocides, 4,4'-(1,6-hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium++ + iodide)s.

作者信息

Maeda T, Manabe Y, Yamamoto M, Yoshida M, Okazaki K, Nagamune H, Kourai H

机构信息

Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1999 Jul;47(7):1020-3. doi: 10.1248/cpb.47.1020.

DOI:10.1248/cpb.47.1020

PMID:10434404

Abstract

Potent new biocides against both bacteria and fungi, 4,4'-(1,6-hexamethylenedioxydicarbonyl)bis(1-alkylpyridinium iodide)s (4DOCBP-6,n) (alkyl chain length, n = 8, 10, 12, 14, 16 and 18) were synthesized, 4DOCBP-6,n is a bis-quaternary ammonium compound (bis-QAC) and has a symmetrical dimeric structure which is composed of two alkylpyridinium iodides connected with a hexamethylenedioxydicarbonyl chain. 4DOCBP-6,10 and 4DOCBP-6,12 exhibited wide and effective antimicrobial spectra, compared with those of typical bactericides, N-dodecylpyridinium iodides (P-12) and benzyldimethyldodecylammonium chloride (BAC), or a popularly-used fungicide, 2-(4-thiazolyl)benzimidazole (TBZ). Their superior properties would be due to the unique dimeric structure which contains two active moieties in a molecule.

摘要

合成了对细菌和真菌均有效的新型强力杀菌剂4,4'-(1,6-己二亚甲基二氧二羰基)双(1-烷基碘化吡啶)盐(4DOCBP-6,n)(烷基链长度n = 8、10、12、14、16和18)，4DOCBP-6,n是一种双季铵化合物(bis-QAC)，具有对称的二聚体结构，由两个通过己二亚甲基二氧二羰基链连接的烷基碘化吡啶组成。与典型的杀菌剂N-十二烷基碘化吡啶(P-12)和苄基二甲基十二烷基氯化铵(BAC)或常用的杀菌剂2-(4-噻唑基)苯并咪唑(TBZ)相比，4DOCBP-6,10和4DOCBP-6,12表现出广泛且有效的抗菌谱。它们的优异性能归因于分子中含有两个活性部分的独特二聚体结构。