Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey.
Molecules. 2009 Dec 14;14(12):5203-15. doi: 10.3390/molecules14125203.
Some substituted benzylidenehydrazinylpyridinium derivatives bearing benzyl, ethylphenyl and propylphenyl groups on the pyridinium nitrogen were synthesized and screened for possible antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans using the microdilution method. Antimicrobial test results indicated that compounds containing a 3-phenylpropyl chain displayed the highest antimicrobial activity against Staphylococcus aureus and the compound 3d was the most active in the series against all tested bacteria and fungi strains.
一些取代的苯亚甲基肼基吡啶鎓衍生物在吡啶鎓氮上带有苄基、乙基苯基和丙基苯基，采用微量稀释法对金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌和白色念珠菌进行了可能的抗菌和抗真菌活性筛选。抗菌试验结果表明，含有 3-苯基丙基链的化合物对金黄色葡萄球菌显示出最高的抗菌活性，而化合物 3d 是该系列中对所有测试的细菌和真菌菌株最活跃的化合物。
