Zhu L, Yang X, Song H
Peking Union Medical College, Beijing 100730.
Zhonghua Fu Chan Ke Za Zhi. 1999 Oct;34(10):618-20.
To explore the risk of pregnancy in patients conceived within one year after successful chemotherapy for gestational trophoblastic tumor.
22 patients conceived within one year after chemotherapy were followed up and analysed about abnormal pregnant result, wastage rate and the time of interval between chemotherapy and pregnancy.
Among 22 cases, 9 cases were full term birth, 6 cases were wastage. The wastage rate was 27.3%. The wastage rate of these patients conceived within half a year was higher than one year (P < 0.05). 1 repeated hydatidiform mole and one post term choriocarcinoma occurred in 22 patients. They both were conceived within 5 months after chemotherapy.
Preservation of fertility is feasible in patients suffering from choriocarcimona and invasive mole. But these patients should practise contraception at least half a year after chemotherapy, and it's better to advise patients to take contraception for one year.
探讨妊娠滋养细胞肿瘤化疗成功后一年内受孕患者的妊娠风险。
对化疗后一年内受孕的22例患者进行随访，分析其妊娠结局异常情况、流产率以及化疗与妊娠的间隔时间。
22例患者中，9例足月分娩，6例流产。流产率为27.3%。半年内受孕患者的流产率高于一年内受孕患者（P<0.05）。22例患者中发生1例重复性葡萄胎和1例过期绒毛膜癌，二者均在化疗后5个月内受孕。
绒毛膜癌和侵蚀性葡萄胎患者保留生育功能是可行的。但这些患者化疗后至少应避孕半年，建议避孕一年更好。
