Procter A W, Qurne M, Francis P T
Department of Psychiatry, Manchester Royal Infirmary, Manchester, UK.
Dement Geriatr Cogn Disord. 1999;10 Suppl 1:80-4. doi: 10.1159/000051219.
This study examines neurochemical measures of cholinergic, serotonergic and glutamatergic innervation in frontal temporal and parietal cerebral cortex from 16 subjects with frontotemporal dementia (FTD) including 10 subjects with Pick pathology and 6 with dementia of frontal lobe type (DFT) together with 9 subjects with Alzheimer's disease, and 28 matched controls. In both forms of FTD there was not evidence of any cholinergic abnormality, unlike the situation in AD. Serotonin receptors were lost from frontal and temporal cortex in FTD and from temporal and parietal cortex in AD. In FTD there was no loss of kainate receptors but loss of AMPA receptors from both temporal and frontal lobes. Loss of AMPA receptors differentiated Pick-type FTD from DFT. These results are interpreted to indicate selective losses of subpopulations of cortical pyramidal neurones.
本研究检测了16例额颞叶痴呆（FTD）患者（其中10例有Pick病理改变，6例为额叶型痴呆（DFT））、9例阿尔茨海默病患者以及28例匹配对照者的额颞叶和顶叶大脑皮质中胆碱能、5-羟色胺能和谷氨酸能神经支配的神经化学指标。与阿尔茨海默病的情况不同，在两种形式的FTD中均未发现任何胆碱能异常。5-羟色胺受体在FTD患者的额叶和颞叶皮质以及AD患者的颞叶和顶叶皮质中丢失。在FTD中，红藻氨酸受体未丢失，但颞叶和额叶的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体丢失。AMPA受体的丢失区分了Pick型FTD和DFT。这些结果被解释为表明皮质锥体细胞亚群的选择性丢失。
