氧化应激在额颞叶痴呆中的作用。

Role of oxidative stress in frontotemporal dementia.

作者信息

Gerst J L, Siedlak S L, Nunomura A, Castellani R, Perry G, Smith M A

机构信息

Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

出版信息

Dement Geriatr Cogn Disord. 1999;10 Suppl 1:85-7. doi: 10.1159/000051220.

DOI:10.1159/000051220

PMID:10436348

Abstract

Recent reports have established oxidative stress and damage as playing a role in the pathogenesis of a number of neurodegenerative diseases including Alzheimer disease, Parkinson disease, corticobasal degeneration, Pick's disease and Alexander's disease. Here we present evidence that oxidative damage is also one of the earliest cytopathological markers of neuronal dysfunction in frontotemporal dementia.

摘要

近期报告已证实氧化应激和损伤在包括阿尔茨海默病、帕金森病、皮质基底节变性、皮克病和亚历山大病在内的多种神经退行性疾病的发病机制中发挥作用。在此，我们提供证据表明氧化损伤也是额颞叶痴呆中神经元功能障碍最早的细胞病理学标志物之一。