Hanson E S, Leibold E A
Department of Medicine, University of Utah, Salt Lake City 84112, USA.
Gene Expr. 1999;7(4-6):367-76.
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA binding proteins that posttranscriptionally regulate the expression of mRNAs coding for proteins involved in the maintenance of iron and energy homeostasis. The RNA binding activities of the IRPs are regulated by changes in cellular iron. Thus, the IRPs are considered iron sensors and the principle regulators of cellular iron homeostasis. The mechanisms governing iron regulation of the IRPs are well described. Recently, however, much attention has focused on the regulation of IRPs by reactive nitrogen and oxygen species (RNS, ROS). Here we focus on summarizing the iron-regulated RNA binding activities of the IRPs, as well as the recent findings of IRP regulation by RNS and ROS. The recent observations that changes in oxygen tension regulate both IRP1 and IRP2 RNA binding activities will be addressed in light of ROS regulation of the IRPs.
铁调节蛋白1和2（IRP1和IRP2）是RNA结合蛋白，它们在转录后调节编码参与维持铁和能量稳态的蛋白质的mRNA的表达。IRP的RNA结合活性受细胞内铁含量变化的调节。因此，IRP被认为是铁传感器和细胞铁稳态的主要调节因子。关于IRP铁调节的机制已有详细描述。然而，最近，人们的注意力大多集中在活性氮和氧物种（RNS、ROS）对IRP的调节上。在这里，我们着重总结IRP的铁调节RNA结合活性，以及RNS和ROS对IRP调节的最新发现。鉴于ROS对IRP的调节作用，我们将探讨最近关于氧张力变化调节IRP1和IRP2 RNA结合活性的观察结果。
