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缺氧调控下的线粒体组成与功能。

Mitochondrial composition and function under the control of hypoxia.

作者信息

Fuhrmann Dominik C, Brüne Bernhard

机构信息

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany; Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology, 60596 Frankfurt, Germany.

出版信息

Redox Biol. 2017 Aug;12:208-215. doi: 10.1016/j.redox.2017.02.012. Epub 2017 Feb 24.

DOI:10.1016/j.redox.2017.02.012
PMID:28259101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5333533/
Abstract

Hypoxia triggers several mechanisms to adapt cells to a low oxygen environment. Mitochondria are major consumers of oxygen and a potential source of reactive oxygen species (ROS). In response to hypoxia they exchange or modify distinct subunits of the respiratory chain and adjust their metabolism, especially lowering the citric acid cycle. Intermediates of the citric acid cycle participate in regulating hypoxia inducible factors (HIF), the key mediators of adaptation to hypoxia. Here we summarize how hypoxia conditions mitochondria with consequences for ROS-production and the HIF-pathway.

摘要

缺氧触发多种机制以使细胞适应低氧环境。线粒体是氧气的主要消耗者和活性氧（ROS）的潜在来源。在缺氧反应中，它们会交换或修饰呼吸链的不同亚基并调整其代谢，特别是降低柠檬酸循环。柠檬酸循环的中间产物参与调节缺氧诱导因子（HIF），这是适应缺氧的关键介质。在这里，我们总结了缺氧如何影响线粒体，进而对ROS产生和HIF途径产生影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/d8b64b366ea5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/c84c569f3131/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/4c5d1674fef1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/895a91a3a4e8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/71ccb004e7a5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/dc5a19b6031d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/cac30861b388/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/c9d8a17fb0eb/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/be34104d695c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/1cfb3d67f6b0/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/69d9a1215b68/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/d8b64b366ea5/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/c84c569f3131/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/4c5d1674fef1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/895a91a3a4e8/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/71ccb004e7a5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/dc5a19b6031d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/cac30861b388/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/c9d8a17fb0eb/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/be34104d695c/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/1cfb3d67f6b0/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/69d9a1215b68/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c0ac/5333533/d8b64b366ea5/gr10.jpg

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