Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Education Office, Pasteur Institute of Iran, Tehran, Iran.
BMC Med Genomics. 2022 Aug 6;15(1):175. doi: 10.1186/s12920-022-01328-3.
Sulfur mustard (SM) is an alkylating and forming chemical that was widely used by Iraqi forces during the Iran-Iraq wars. One of the target organs of SM is the skin. Understanding the mechanisms involved in the pathogenesis of SM may help better identify complications and find appropriate treatments. The current study collected ten SM-exposed patients with long-term skin complications and ten healthy individuals. Proteomics experiments were performed using the high-efficiency TMT10X method to evaluate the skin protein profile, and statistical bioinformatics methods were used to identify the differentially expressed proteins. One hundred twenty-nine proteins had different expressions between the two groups. Of these 129 proteins, 94 proteins had increased expression in veterans' skins, while the remaining 35 had decreased expression. The hub genes included RPS15, ACTN1, FLNA, HP, SDHC, and RPL29, and three modules were extracted from the PPI network analysis. Skin SM exposure can lead to oxidative stress, inflammation, apoptosis, and cell proliferation.
硫芥（SM）是一种烷化剂和形成化学物质，在两伊战争期间被伊拉克军队广泛使用。SM 的靶器官之一是皮肤。了解 SM 发病机制中涉及的机制可能有助于更好地识别并发症并找到合适的治疗方法。本研究收集了 10 名长期皮肤并发症的 SM 暴露患者和 10 名健康个体。使用高效 TMT10X 方法进行蛋白质组学实验，评估皮肤蛋白谱，并使用统计生物信息学方法鉴定差异表达蛋白。两组之间有 129 种蛋白表达不同。在这 129 种蛋白质中，有 94 种在退伍军人的皮肤中表达增加，而其余 35 种则表达减少。核心基因包括 RPS15、ACTN1、FLNA、HP、SDHC 和 RPL29，从 PPI 网络分析中提取了三个模块。皮肤 SM 暴露可导致氧化应激、炎症、细胞凋亡和细胞增殖。
