Aksit S, Egemen A, Ozacar T, Kurugol Z, Keskinoglu P, Tasbakan M, Caglayan S
Department of Pediatrics, Ege University Medical Faculty, Izmir, Turkey.
Pediatr Infect Dis J. 1999 Jul;18(7):577-80. doi: 10.1097/00006454-199907000-00003.
The European Advisory Group on the Expanded Program on Immunization of WHO has recommended that by 2010 or earlier congenital rubella should be well-controlled or eliminated in all countries in Europe. Debate on the introduction of rubella vaccine into national immunization schedules continues to occur, and data on rubella and congenital rubella syndrome in Turkey are insufficient.
To determine age-specific rubella seroprevalence in the 1- to 29-year-old unvaccinated population in Izmir, Turkey.
A total of 600 unvaccinated persons 1 to 29 years old were selected for the study with cluster sampling in Izmir, Turkey. The information on sociodemographic characteristics and disease history was gathered for each participant, and in 580 of them rubella-specific IgG antibodies were assayed quantitatively by the micro-enzyme immunoassay.
Of the 580 participants tested for rubella antibodies, 135 (23.3%) were seronegative. The proportions of susceptible individuals were 61.7, 29.5, 12.4, 10.3 and 8.4% in the age groups of 1 to 4, 5 to 9, 10 to 14, 15 to 19 and 20 to 29 years, respectively. Of the young women 15 to 19 years of age, 13.5% were susceptible to rubella infection.
Because a substantial proportion of women in their childbearing years are susceptible to rubella, immunization efforts should be directed at infants or prepubertal children.
世界卫生组织扩大免疫规划欧洲咨询小组建议，到2010年或更早，欧洲所有国家应有效控制或消除先天性风疹。关于将风疹疫苗纳入国家免疫规划的讨论仍在继续，而土耳其风疹和先天性风疹综合征的数据不足。
确定土耳其伊兹密尔1至29岁未接种疫苗人群中特定年龄的风疹血清阳性率。
在土耳其伊兹密尔采用整群抽样法选取600名1至29岁未接种疫苗的人员进行研究。收集每位参与者的社会人口学特征和疾病史信息，其中580人通过微酶免疫测定法定量检测风疹特异性IgG抗体。
在580名检测风疹抗体的参与者中，135人（23.3%）血清学阴性。1至4岁、5至9岁、10至14岁、15至19岁和20至29岁年龄组中易感个体的比例分别为61.7%、29.5%、12.4%、10.3%和8.4%。15至19岁的年轻女性中，13.5%易感染风疹。
由于育龄期相当一部分女性易感染风疹，免疫工作应针对婴儿或青春期前儿童。
