Maeda K, Kang S M, Onoda N, Ogawa M, Kato Y, Sawada T, Chung K H
First Department of Surgery, Osaka City University Medical School, Osaka, Japan.
Cancer. 1999 Aug 15;86(4):566-71. doi: 10.1002/(sici)1097-0142(19990815)86:4<566::aid-cncr4>3.0.co;2-1.
Recently many studies have demonstrated that the degree of tumor angiogenesis is related to the aggressiveness of the tumor and clinical outcome. Vascular endothelial growth factor (VEGF) is a well characterized inducer of angiogenesis. In this study, the authors investigated the prognostic significance of VEGF expression in patients with early gastric carcinoma together with p53 gene abnormality and tumor cell proliferation.
One hundred ninety-five endoscopically biopsied specimens obtained preoperatively from patients with early gastric carcinoma were studied immunohistochemically.
According to conventional clinicopathologic factors, submucosal invasion, lymph node metastases, and tumor size were associated significantly with the incidence of disease recurrence. According to conventional biologic factors, VEGF expression was observed more frequently in patients with disease recurrence compared with those without disease recurrence whereas neither p53 abnormality nor tumor cell proliferation were correlated with prognosis. Moreover, multivariate analysis indicated that VEGF expression (as well as submucosal invasion and lymph node metastases) is an independent predictor of disease recurrence.
The results of the current study show that VEGF expression may be a useful prognostic factor for patients with early gastric carcinoma.
最近许多研究表明，肿瘤血管生成程度与肿瘤侵袭性及临床结局相关。血管内皮生长因子（VEGF）是一种已被充分表征的血管生成诱导因子。在本研究中，作者探讨了VEGF表达联合p53基因异常及肿瘤细胞增殖在早期胃癌患者中的预后意义。
对195例术前经内镜活检获取的早期胃癌患者标本进行免疫组织化学研究。
根据传统临床病理因素，黏膜下浸润、淋巴结转移及肿瘤大小与疾病复发率显著相关。根据传统生物学因素，与未复发患者相比，复发患者中VEGF表达更为常见，而p53异常及肿瘤细胞增殖均与预后无关。此外，多因素分析表明，VEGF表达（以及黏膜下浸润和淋巴结转移）是疾病复发的独立预测因素。
本研究结果表明，VEGF表达可能是早期胃癌患者有用的预后因素。
