Jaffe L F
Dept. OB/GYN, Women & Infants Hospital, Brown University, 101 Dudley Street, Providence, Rhode Island 01905, USA.
Bioessays. 1999 Aug;21(8):657-67. doi: 10.1002/(SICI)1521-1878(199908)21:8<657::AID-BIES5>3.0.CO;2-K.
This survey focuses on early or primitive developmental phenomena for which the location of a steady high calcium region or the direction of a calcium wave is critical and calcium is more than a trigger. It starts with the long studied roles of calcium in fucoid eggs and in Dictyostelium and progresses to newer work on high calcium regions in medaka fish, zebrafish, and Drosophila eggs. It then proposes that propagated, ultraslow developmental waves in six diverse systems indicate a new and important class of calcium waves. These include the morphogenetic furrow in Drosophila eye discs, floret formation in sunflowers, DNA replication waves in protozoan macronuclei, growth-cone like waves in hippocampal neurons, and two others. It then considers the possible organizing roles of slow calcium waves. Here, it emphasizes surface contractile waves during primary neural induction and elsewhere as well as the possibility of cellular peristalsis. Finally, it reviews the organizing roles of fast calcium waves in ascidian eggs.
本调查聚焦于早期或原始发育现象，对于这些现象而言，稳定高钙区域的位置或钙波的方向至关重要，且钙不仅仅是一个触发因素。它始于长期以来对钙在褐藻卵和盘基网柄菌中的作用的研究，进而发展到对青鳉鱼、斑马鱼和果蝇卵中高钙区域的新研究。然后提出，在六个不同系统中传播的超慢发育波表明存在一类新的重要钙波。这些包括果蝇眼盘中的形态发生沟、向日葵中的小花形成、原生动物大核中的DNA复制波、海马神经元中类似生长锥的波，以及另外两种。接着探讨了慢钙波可能的组织作用。在此，强调了初级神经诱导及其他部位的表面收缩波以及细胞蠕动的可能性。最后，回顾了快速钙波在海鞘卵中的组织作用。
