Ribeiro J A
Laboratory of Neurosciences, Faculty of Medicine, University of Lisbon, Portugal.
Eur J Pharmacol. 1999 Jun 30;375(1-3):101-13. doi: 10.1016/s0014-2999(99)00230-7.
Adenosine, by activating adenosine A2A receptors, seems to have a crucial function in regulating the activation of multiple receptors that affect neurotransmitter release and/or synaptic transmission, in particular receptors for neuropeptides (calcitonin gene related peptide (CGRP) and vasoactive intestinal peptide (VIP)), and NMDA receptors, metabotropic glutamate receptors, nicotinic autofacilitatory receptors, dopamine receptors and adenosine A1 receptors. The manner in which these A2A receptors are involved in interactions with the receptors for other neurotransmitters and or neuromodulators opens novel avenues for the action of this 'omnipresent' nucleoside. Either by direct receptor-receptor modulation or by post-receptor mechanisms, adenosine, in its 'obsession' to protect cells from insults, uses as many receptor systems as possible to synchronize synaptic transmission, in order to exert what seems to be the 'destiny' of this nucleoside--protection of the nervous system.
腺苷通过激活腺苷A2A受体，似乎在调节多种影响神经递质释放和/或突触传递的受体的激活中发挥关键作用，特别是神经肽（降钙素基因相关肽（CGRP）和血管活性肠肽（VIP））的受体，以及N-甲基-D-天冬氨酸（NMDA）受体、代谢型谷氨酸受体、烟碱自促进受体、多巴胺受体和腺苷A1受体。这些A2A受体参与与其他神经递质和/或神经调质受体相互作用的方式，为这种“无所不在”的核苷的作用开辟了新途径。无论是通过直接的受体-受体调节还是通过受体后机制，腺苷在其“保护细胞免受损伤”的“执着”中，尽可能多地利用受体系统来同步突触传递，以实现这种核苷似乎的“使命”——保护神经系统。
