Anttila S S, Knuuttila M L, Sakki T K
Department of Periodontology and Geriatric Dentistry, Institute of Dentistry, University of Oulu, Finland.
Psychosom Med. 1999 Jul-Aug;61(4):508-12. doi: 10.1097/00006842-199907000-00015.
The purpose was to study the growth of lactobacilli in subjects with depressive symptoms in the total 55-year-old population of Oulu (a medium-sized town in Finland); 780 people participated.
The dental examination included measurements of salivary lactobacillus growth with the Dentocult-LB method; measurements of salivary flow rate, pH, and buffering capacity; and assessment of oral health status. Depressive symptoms were determined with the Zung Self-Rating Depression Scale (ZSDS). Participants were also asked about their health, medication, smoking, and dietary habits.
The prevalence of high lactobacillus counts (> or =100,000 CFU/ml) was 22% among women and 31% among men (p = .02). Thirty-seven percent of the subjects with a high rate of depressive symptoms (ZSDS score of > or = 40) and 23% of those with an ZSDS score of < or = 39 had high counts of lactobacilli (p = .003). A logistic regression analysis with improvement of goodness of fit was made to confirm the relation between abundant lactobacilli and a high rate of depressive symptoms. After the confounding factors had been added stepwise into the logistic regression model, depressive symptoms were still significantly associated with abundant lactobacillus growth.
The association between high lactobacillus counts and depressive symptoms suggests that depressed subjects are at risk of having caries and possibly other dental diseases that should be recognized in the treatment of these patients.
研究在芬兰中等规模城镇奥卢的55岁总人口中，有抑郁症状的受试者体内乳酸杆菌的生长情况；780人参与了此项研究。
牙科检查包括使用Dentocult-LB方法测量唾液中乳酸杆菌的生长情况；测量唾液流速、pH值和缓冲能力；以及评估口腔健康状况。使用zung自评抑郁量表（ZSDS）确定抑郁症状。还询问了参与者的健康状况、用药情况、吸烟情况和饮食习惯。
女性中乳酸杆菌计数高（≥100,000 CFU/ml）的患病率为22%，男性为31%（p = 0.02）。抑郁症状发生率高（ZSDS评分≥40）的受试者中有37%，ZSDS评分≤39的受试者中有23%乳酸杆菌计数高（p = 0.003）。进行了逻辑回归分析以改善拟合优度，以确认丰富的乳酸杆菌与高抑郁症状发生率之间的关系。在将混杂因素逐步添加到逻辑回归模型后，抑郁症状仍与丰富的乳酸杆菌生长显著相关。
高乳酸杆菌计数与抑郁症状之间的关联表明，抑郁患者有患龋齿及可能其他牙科疾病的风险，在这些患者的治疗中应予以重视。
