de Vries E, de Groot R, de Bruin-Versteeg S, Comans-Bitter W M, van Dongen J J
Department of Immunology, Erasmus University Rotterdam, The Netherlands.
Eur J Pediatr. 1999 Aug;158(8):611-7. doi: 10.1007/s004310051162.
Technical developments in immunophenotyping and function testing have greatly facilitated studies on the developing lymphocyte system in the past decade and contributed to a better interpretation of the data obtained in these studies. This is important for the correct interpretation of data obtained in paediatric patients with possible immunological diseases. The age-related differences in lymphocyte subpopulations and function imply that the available adult reference values cannot be used in children.
In this review we give an outline of the technical developments, their influence upon the interpretation of data, and the available literature about age-related changes in the developing lymphocyte system.
在过去十年中，免疫表型分析和功能测试方面的技术发展极大地推动了对发育中的淋巴细胞系统的研究，并有助于更好地解释这些研究中获得的数据。这对于正确解释可能患有免疫性疾病的儿科患者所获得的数据非常重要。淋巴细胞亚群和功能的年龄相关差异意味着现有的成人参考值不能用于儿童。
在本综述中，我们概述了技术发展、它们对数据解释的影响以及有关发育中的淋巴细胞系统年龄相关变化的现有文献。
