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本文引用的文献

1

HIV-exposed uninfected children: a growing population with a vulnerable immune system?HIV 暴露但未感染的儿童：免疫系统脆弱的不断增长的人群？

Clin Exp Immunol. 2014 Apr;176(1):11-22. doi: 10.1111/cei.12251.

2

The impact of maternal HIV infection on cord blood lymphocyte subsets and cytokine profile in exposed non-infected newborns.母体 HIV 感染对暴露于感染但未感染的新生儿脐带血淋巴细胞亚群和细胞因子谱的影响。

BMC Infect Dis. 2011 Feb 3;11:38. doi: 10.1186/1471-2334-11-38.

3

Evidence of impact of maternal HIV infection on immunoglobulin levels in HIV-exposed uninfected children.母亲感染艾滋病毒对未感染艾滋病毒儿童免疫球蛋白水平影响的证据。

AIDS Res Hum Retroviruses. 2010 Sep;26(9):967-75. doi: 10.1089/aid.2009.0241.

4

HV-1-specific cytotoxic T lymphocytes and breast milk HIV-1 transmission.针对人疱疹病毒1型的细胞毒性T淋巴细胞与母乳传播HIV-1

J Infect Dis. 2009 Mar 15;199(6):889-98. doi: 10.1086/597120.

5

Imbalance of naive and memory T lymphocytes with sustained high cellular activation during the first year of life from uninfected children born to HIV-1-infected mothers on HAART.在接受高效抗逆转录病毒治疗（HAART）的HIV-1感染母亲所生未感染儿童生命的第一年，幼稚和记忆T淋巴细胞失衡，细胞持续高度活化。

Braz J Med Biol Res. 2008 Aug;41(8):700-8. doi: 10.1590/s0100-879x2008000800011.

6

Strong HIV-1-specific T cell responses in HIV-1-exposed uninfected infants and neonates revealed after regulatory T cell removal.经调节性 T 细胞清除后，HIV-1 暴露未感染婴儿和新生儿中可检测到强烈的 HIV-1 特异性 T 细胞反应。

PLoS One. 2006 Dec 20;1(1):e102. doi: 10.1371/journal.pone.0000102.

7

Increased CD154 expression in uninfected infants born to HIV-positive mothers exposed to antiretroviral prophylaxis.暴露于抗逆转录病毒预防措施的HIV阳性母亲所生未感染婴儿中CD154表达增加。

Viral Immunol. 2006 Summer;19(3):363-72. doi: 10.1089/vim.2006.19.363.

8

Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts.HIV阳性母亲的HIV阴性婴儿中祖细胞功能受损，导致胸腺输出减少和CD4细胞计数低。

Blood. 2001 Jul 15;98(2):398-404. doi: 10.1182/blood.v98.2.398.

9

T-helper cell responses to HIV envelope peptides in cord blood: protection against intrapartum and breast-feeding transmission.脐带血中T辅助细胞对HIV包膜肽的反应：预防分娩期间和母乳喂养传播。

AIDS. 2001 Jan 5;15(1):1-9. doi: 10.1097/00002030-200101050-00003.

10

T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV.未感染但垂直感染HIV的新生儿和儿童的T淋巴细胞成熟异常。

Blood. 2000 Dec 1;96(12):3866-71.

HIV 暴露未感染婴儿和未暴露未感染婴儿的淋巴细胞亚群。

Lymphocyte subsets in HIV-exposed uninfected infants and HIV-unexposed uninfected infants.

机构信息

Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Mass.

Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Mass.

出版信息

J Allergy Clin Immunol. 2017 Aug;140(2):605-608.e3. doi: 10.1016/j.jaci.2017.01.033. Epub 2017 Mar 6.

DOI:10.1016/j.jaci.2017.01.033

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5546944/

Abstract

HEU infants had higher CD19 B cell counts and % than HUU infants after the first 3 months of life, suggesting a B cell immune response with intrauterine exposure to maternal HIV or other pathogens.

摘要

HEU 婴儿在生命的头 3 个月后，其 CD19 B 细胞计数和百分比均高于 HUU 婴儿，提示宫内暴露于母体 HIV 或其他病原体后出现 B 细胞免疫应答。