Su Y, Ahsan H, Neugut A I
Division of Epidemiology, Joseph L. Mailman School of Public Health, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Am J Gastroenterol. 1999 Aug;94(8):2256-62. doi: 10.1111/j.1572-0241.1999.01302.x.
Cancers of the biliary tract, including cancers of the gallbladder and bile duct, generally carry a very poor prognosis. Little is known about their etiology. The pattern of co-occurrence of two cancers may give clues to shared etiological risk factors. We therefore investigated the association of biliary tract cancer with other cancers, especially with estrogen- and tobacco-related cancers.
We used data from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. Associations between biliary tract cancer and other cancers were evaluated using the standardized incidence ratio as an estimate of the relative risk of a second primary malignancy.
Estrogen-related cancers of the breast and uterine corpus and smoking-related upper aerodigestive tract cancers were not associated with biliary tract cancer. The risk of gallbladder cancer was inversely related to the risk of prostate cancer in men, but positively related to the risk of cervical cancer in women.
This study suggests that smoking and estrogen exposure have minimal roles in the pathogenesis of biliary tract cancer. Our finding of an inverse relationship between prostate cancer and gallbladder cancer requires confirmation by further studies.
包括胆囊癌和胆管癌在内的胆道癌通常预后很差。人们对其病因知之甚少。两种癌症同时发生的模式可能为共同的病因风险因素提供线索。因此，我们研究了胆道癌与其他癌症的关联，尤其是与雌激素和烟草相关癌症的关联。
我们使用了美国国立癌症研究所监测、流行病学和最终结果计划的数据。使用标准化发病率比评估胆道癌与其他癌症之间的关联，作为估计第二种原发性恶性肿瘤相对风险的指标。
乳腺癌和子宫体的雌激素相关癌症以及吸烟相关的上消化道癌症与胆道癌无关。男性胆囊癌风险与前列腺癌风险呈负相关，但与女性宫颈癌风险呈正相关。
本研究表明，吸烟和雌激素暴露在胆道癌发病机制中的作用极小。我们发现前列腺癌与胆囊癌之间存在负相关关系，这一发现需要进一步研究加以证实。
