Nectoux J, Coleman M P
Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France.
Rev Epidemiol Sante Publique. 1993;41(2):113-22.
Incidence data from a large number of cancer registries throughout the world are presented for cancers at various sub-sites of the biliary tract, to assess whether the epidemiology of gall bladder cancer can be distinguished from cancer of the extra-hepatic bile ducts and cancer of the ampulla of Vater. Cancers of the biliary tract appear to be strongly sex-related. A marked genetic susceptibility emerges from this review, not only for gall bladder cancer, as previously reported for American Indians, but also perhaps for cancer of the extrahepatic bile ducts, for which Japanese of both sexes have high rates. Mortality data for all biliary tract (mainly gall bladder) cancer are examined for the period 1958-85. A wide range of trends is observed, notably a consistent decline in mortality among Anglo-Saxon populations, for both males and females. Dietary factors, possibly mediated through hormonal and genetic factors, are suggested as a major causal influence on biliary tract cancers.
本文展示了来自世界各地大量癌症登记处的发病率数据，这些数据涉及胆道各个亚部位的癌症，目的是评估胆囊癌的流行病学特征是否能与肝外胆管癌和 Vater 壶腹癌区分开来。胆道癌似乎与性别密切相关。通过本次综述发现了明显的遗传易感性，不仅对于胆囊癌如此，正如之前报道的美国印第安人那样，而且对于肝外胆管癌可能也是如此，日本男女患肝外胆管癌的比例都很高。研究了1958年至1985年期间所有胆道（主要是胆囊）癌的死亡率数据。观察到了广泛的趋势，尤其是盎格鲁 - 撒克逊人群中男性和女性的死亡率持续下降。饮食因素可能通过激素和遗传因素起作用，被认为是胆道癌的主要因果影响因素。
