Strom B L, Hibberd P L, Soper K A, Stolley P D, Nelson W L
Cancer Res. 1985 Oct;45(10):5165-8.
Previous studies of the descriptive epidemiology of biliary tract cancers have not differentiated among different types of biliary tract cancer because until recently the International Classification of Diseases (ICD) did not classify them separately. Recent versions of the ICD now distinguish cancers of the gallbladder, extrahepatic bile ducts, and ampulla of Vater. In order to describe more precisely the distribution of these three cancers, we obtained data from nine cancer registries throughout the world which used the eighth or ninth revision of the ICD. Sex-specific, age-adjusted disease rates were calculated for each disease. Log-linear models were used to evaluate the association of age and sex with the risk of acquiring each disease and to assess whether the risk of acquiring disease or the age and sex distribution of the three diseases varied by geographic location. Gallbladder cancer was the most common of the three diseases and occurred more frequently in females. Extrahepatic bile duct cancer was the next most common disease and occurred equally in both sexes. Cancer of the ampulla of Vater was the least common and was more common in males. The incidence of each of the diseases increased with age. The age and sex distributions of the different diseases different among the nine registries. Thus these three neoplasms differ in their descriptive epidemiology and should therefore be considered separately in clinical practice and in future investigations.
以往关于胆道癌描述性流行病学的研究并未区分不同类型的胆道癌，因为直到最近，国际疾病分类（ICD）都没有对它们进行单独分类。ICD的最新版本现在区分了胆囊癌、肝外胆管癌和壶腹癌。为了更精确地描述这三种癌症的分布情况，我们从全球九个使用ICD第八版或第九版的癌症登记处获取了数据。计算了每种疾病的性别特异性、年龄调整发病率。使用对数线性模型评估年龄和性别与患每种疾病风险的关联，并评估患疾病的风险或这三种疾病的年龄和性别分布是否因地理位置而异。胆囊癌是这三种疾病中最常见的，在女性中更为常见。肝外胆管癌是第二常见的疾病，在男女中发病率相同。壶腹癌是最不常见的，在男性中更为常见。每种疾病的发病率都随年龄增长而增加。这九种登记处中不同疾病的年龄和性别分布有所不同。因此，这三种肿瘤在描述性流行病学方面存在差异，因此在临床实践和未来研究中应分别考虑。
