Velísková J, Moshé S L, Vathy I
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Brain Res Dev Brain Res. 1999 Aug 5;116(1):119-21. doi: 10.1016/s0165-3806(99)00068-1.
We examined the effect of prenatal morphine exposure (5-10 mg/kg on days 11-18 of gestation) on seizure susceptibility in female rats during development. The effect of morphine exposure on flurothyl-induced seizures was age-dependent. At postnatal day (PN) 15, morphine exposure decreased both clonic and tonic-clonic seizure thresholds compare to saline controls. At PN 25, morphine exposure did not alter the clonic seizure threshold but increased the threshold to tonic-clonic seizure. At PN 38, morphine exposure did not influence either threshold. The data suggest that the effects of prenatal exposure to opioids on seizures are age-related and transient.
我们研究了孕期吗啡暴露（妊娠第11 - 18天给予5 - 10毫克/千克）对雌性大鼠发育过程中癫痫易感性的影响。吗啡暴露对氟烷诱发癫痫的影响具有年龄依赖性。在出生后第15天，与生理盐水对照组相比，吗啡暴露降低了阵挛性和强直 - 阵挛性癫痫阈值。在出生后第25天，吗啡暴露未改变阵挛性癫痫阈值，但提高了强直 - 阵挛性癫痫阈值。在出生后第38天，吗啡暴露对两种阈值均无影响。数据表明，产前暴露于阿片类药物对癫痫的影响与年龄相关且是短暂的。
