Vathy I, Velísková J, Moshé S L
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Pharmacol Biochem Behav. 1998 Jul;60(3):635-8. doi: 10.1016/s0091-3057(98)00048-3.
The purpose of this study was to investigate the effects of prenatal exposure to morphine (5-10 mg/kg on days 11-18 of gestation) on flurothyl seizure susceptibility in adult and developing male rats. In adult rats, prenatal morphine exposure increased the threshold to clonic seizures but not to tonic-clonic seizures. The effects of prenatal morphine exposure on clonic seizures were age dependent. At postnatal day (PND) 15, prenatal drug exposure did not alter the seizure threshold. At PND 25, there was a reduction in the threshold but by PND 38, the clonic seizure threshold was increased and this increase persisted into adulthood. Prenatal exposure to morphine did not alter the tonic-clonic seizure threshold in any age group of intact male rats. A group of male rats prenatally exposed to morphine was gonadectomized in adulthood. In gonadectomized rats both clonic and tonic-clonic thresholds were increased. These results suggest that exposure to morphine during mid to late gestation induces age-dependent alterations in the susceptibility to clonic but not tonic-clonic seizures. In adult male rats the threshold to tonic-clonic seizures is influenced by prior gonadectomy in adulthood.
本研究的目的是调查孕期暴露于吗啡（妊娠第11 - 18天给予5 - 10毫克/千克）对成年和发育中的雄性大鼠氟烷惊厥易感性的影响。在成年大鼠中，孕期暴露于吗啡增加了阵挛性惊厥的阈值，但对强直 - 阵挛性惊厥阈值没有影响。孕期暴露于吗啡对阵挛性惊厥的影响具有年龄依赖性。在出生后第15天（PND 15），孕期药物暴露未改变惊厥阈值。在PND 25时，阈值降低，但到PND 38时，阵挛性惊厥阈值升高，且这种升高持续到成年期。孕期暴露于吗啡未改变任何年龄组完整雄性大鼠的强直 - 阵挛性惊厥阈值。一组孕期暴露于吗啡的雄性大鼠在成年后进行了性腺切除。在性腺切除的大鼠中，阵挛性和强直 - 阵挛性惊厥阈值均升高。这些结果表明，妊娠中后期暴露于吗啡会导致对阵挛性惊厥而非强直 - 阵挛性惊厥的易感性出现年龄依赖性改变。在成年雄性大鼠中，强直 - 阵挛性惊厥阈值受成年后性腺切除的影响。
