Akahoshi M, Nakashima H, Tanaka Y, Kohsaka T, Nagano S, Ohgami E, Arinobu Y, Yamaoka K, Niiro H, Shinozaki M, Hirakata H, Horiuchi T, Otsuka T, Niho Y
Kyushu University Medical School, Fukuoka, Japan.
Arthritis Rheum. 1999 Aug;42(8):1644-8. doi: 10.1002/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L.
To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic lupus erythematosus (SLE).
The Th1:Th2 ratio was analyzed in 3 groups: SLE without proteinuria (group I; n = 23), SLE with proteinuria (group II; n = 31), and normal controls (group III; n = 24). Group II patients who had undergone renal biopsy were classified into 3 subgroups based on their renal histopathologic findings. The intracellular cytokine detection method with flow cytometry was used to quantitate Th1 and Th2 cells.
There was no difference in the mean Th1:Th2 ratio between SLE patients (groups I and II) and healthy controls (group III). However, the mean value in group II was significantly higher than those in groups I and III. Moreover, within group II, the mean value in SLE patients who had diffuse proliferative lupus nephritis (World Health Organization class IV) was especially high.
Although SLE has been considered to be a disease in which Th2 cells predominate, the Th1/Th2 balance of peripheral Th cells in SLE patients in the present study did not show a predominance of these cells. In contrast, among SLE patients with WHO class IV lupus nephritis, there was a strong predominance of Th1.
分析系统性红斑狼疮（SLE）患者外周血Th细胞的Th1/Th2平衡。
分析3组患者的Th1:Th2比值：无蛋白尿的SLE患者（I组；n = 23）、有蛋白尿的SLE患者（II组；n = 31）和正常对照组（III组；n = 24）。对接受肾活检的II组患者，根据其肾脏组织病理学结果分为3个亚组。采用流式细胞术细胞内细胞因子检测方法对Th1和Th2细胞进行定量分析。
SLE患者（I组和II组）与健康对照组（III组）的平均Th1:Th2比值无差异。然而，II组的平均值显著高于I组和III组。此外，在II组中，患有弥漫性增殖性狼疮性肾炎（世界卫生组织IV级）的SLE患者的平均值尤其高。
尽管SLE被认为是一种以Th2细胞占主导的疾病，但本研究中SLE患者外周血Th细胞的Th1/Th2平衡并未显示出这些细胞的优势。相反，在世界卫生组织IV级狼疮性肾炎的SLE患者中，Th1细胞占明显优势。
