静止期系统性红斑狼疮与正常的Th(1)/Th(2)细胞因子刺激分泌模式相关。
Inactive systemic lupus erythematosus id associated with a normal stimulated Th(1)/Th(2) cytokine secretory pattern.
作者信息
Amit M, Mor A, Weissgarten J, Rosenberg R, Ramot Y, Wysenbeek A J, Rapoport M J
机构信息
Department "B" of Internal Medicine, Assaf Harofeh Medical Center, Zerifin, Israel.
出版信息
Cytokine. 2000 Sep;12(9):1405-8. doi: 10.1006/cyto.2000.0724.
OBJECTIVES
To determine the Th(1)/Th(2)balance in systemic lupus erythematosus (SLE) patients with inactive disease.
METHODS
A comprehensive analysis of peak secretion, overall cytokine production and secretory pattern of Th(1)and Th(2)cytokines from stimulated PBMC of 10 SLE patients with inactive disease and 10 age- and sex-matched controls.
RESULTS
No significant differences were found in the peak and total secretion of all cytokines, as well as in the Th(1)and Th(2)secretory patterns and proliferative response between the two groups.
CONCLUSION
Th(1)and Th(2) balance in inactive SLE is normal.
目的
确定病情处于静止期的系统性红斑狼疮（SLE）患者的Th(1)/Th(2)平衡状态。
方法
对10例病情处于静止期的SLE患者及10例年龄和性别相匹配的对照者的外周血单个核细胞（PBMC）进行刺激，全面分析Th(1)和Th(2)细胞因子的峰值分泌、总体细胞因子产生情况及分泌模式。
结果
两组在所有细胞因子的峰值和总分泌量、Th(1)和Th(2)分泌模式及增殖反应方面均未发现显著差异。
结论
病情静止期的SLE患者Th(1)和Th(2)平衡正常。
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