Kollmar R
Laboratory of Sensory Neuroscience, The Rockefeller University, 1230 York Avenue, Box 314, New York, New York 10021-6399, USA.
Curr Opin Neurobiol. 1999 Aug;9(4):394-8. doi: 10.1016/S0959-4388(99)80059-2.
The mechanosensitive hair bundles of vertebrate hair cells exhibit a remarkable variety of shapes. For a given location in a sensory epithelium, however, the shape and polarity of a hair bundle are specified precisely. Recent findings, in particular with analogous experimental systems of actin polymerization, suggest a model of hair-bundle morphogenesis whereby different Rho guanosine triphosphatases (GTPases) regulate the initiation phase and the elongation phase of local actin-filament assembly at the hair cell's apical membrane.
脊椎动物毛细胞的机械敏感毛束呈现出显著多样的形状。然而，对于感觉上皮中的给定位置，毛束的形状和极性是精确确定的。最近的研究发现，特别是在肌动蛋白聚合的类似实验系统中，提出了一种毛束形态发生模型，即不同的 Rho 鸟苷三磷酸酶（GTP 酶）调节毛细胞顶端膜处局部肌动蛋白丝组装的起始阶段和延伸阶段。
