Neefjes V M, Evelo C T, Baars L G, Blanco C E
Department of Paediatrics Academic Hospital Maastricht PO Box 5800 6202 AZ Maastricht The Netherlands.
Arch Dis Child Fetal Neonatal Ed. 1999 Sep;81(2):F130-3. doi: 10.1136/fn.81.2.f130.
To determine the level of oxidative stress and cell damage as a result of exposure to O(2) at birth.
Using glutathione S transferase (GST) as an indicator of oxidative stress, GST activity in cord blood was compared with that in samples taken three hours after birth. Twenty four prematurely born infants and eight full term infants were studied. To test whether stronger effects occur under less favourable conditions, the neonates were divided in three groups: healthy premature; sick premature; and healthy full term infants.
GST activity three hours after birth was significantly decreased compared with that at birth in all three groups tested. There were no significant differences in the magnitude of this effect among the three groups.
These results indicate that a sudden increase in oxygenation exposes the neonate to oxidative stress. Measurement of GST activity might be useful for the evaluation of protective treatment in trials considering antioxidant strategies.
确定出生时暴露于氧气导致的氧化应激水平和细胞损伤程度。
使用谷胱甘肽S转移酶（GST）作为氧化应激指标，将脐血中的GST活性与出生后三小时采集的样本中的GST活性进行比较。研究了24名早产儿和8名足月儿。为了测试在不太有利的条件下是否会产生更强的影响，将新生儿分为三组：健康早产儿；患病早产儿；和健康足月儿。
在所有三个测试组中，出生后三小时的GST活性与出生时相比均显著降低。三组之间这种影响的程度没有显著差异。
这些结果表明，氧合的突然增加使新生儿暴露于氧化应激中。在考虑抗氧化策略的试验中，测量GST活性可能有助于评估保护性治疗。
