Erythrocyte glutathione S transferase as a marker of oxidative stress at birth.
作者信息
Neefjes V M, Evelo C T, Baars L G, Blanco C E
机构信息
Department of Paediatrics Academic Hospital Maastricht PO Box 5800 6202 AZ Maastricht The Netherlands.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1999 Sep;81(2):F130-3. doi: 10.1136/fn.81.2.f130.
Abstract
AIMS
To determine the level of oxidative stress and cell damage as a result of exposure to O(2) at birth.
METHODS
Using glutathione S transferase (GST) as an indicator of oxidative stress, GST activity in cord blood was compared with that in samples taken three hours after birth. Twenty four prematurely born infants and eight full term infants were studied. To test whether stronger effects occur under less favourable conditions, the neonates were divided in three groups: healthy premature; sick premature; and healthy full term infants.
RESULTS
GST activity three hours after birth was significantly decreased compared with that at birth in all three groups tested. There were no significant differences in the magnitude of this effect among the three groups.
CONCLUSIONS
These results indicate that a sudden increase in oxygenation exposes the neonate to oxidative stress. Measurement of GST activity might be useful for the evaluation of protective treatment in trials considering antioxidant strategies.
摘要
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本文引用的文献
1
Breath pentane as a marker for lipid peroxidation and adverse outcome in preterm infants.
Arch Dis Child Fetal Neonatal Ed. 1998 Jul;79(1):F67-9. doi: 10.1136/fn.79.1.f67.
2
In vitro haematotoxic effects of three methylated hydroxylamines.
Arch Toxicol. 1997;71(5):299-305. doi: 10.1007/s002040050390.
3
Decreased glutathione content and glutathione S-transferase activity in red blood cells of coal miners with early stages of pneumoconiosis.
Br J Ind Med. 1993 Jul;50(7):633-6. doi: 10.1136/oem.50.7.633.
4
Human glutathione S-transferases.
Int J Biochem. 1994 Mar;26(3):295-308. doi: 10.1016/0020-711x(94)90050-7.
5
Reactive oxygen metabolites and reperfusion injury: aberrant triggering of reticuloendothelial function.
Lancet. 1994 Oct 1;344(8927):934-6. doi: 10.1016/s0140-6736(94)92276-4.
6
Site-directed mutagenesis of human glutathione transferase P1-1. Mutation of Cys-47 induces a positive cooperativity in glutathione transferase P1-1.
J Biol Chem. 1995 Jan 20;270(3):1243-8. doi: 10.1074/jbc.270.3.1243.
7
A comparison of erythrocyte glutathione S-transferase activity from human foetuses and adults.
Biochem J. 1980 May 15;188(2):475-9. doi: 10.1042/bj1880475.
8
Assays for differentiation of glutathione S-transferases.
Methods Enzymol. 1981;77:398-405. doi: 10.1016/s0076-6879(81)77053-8.
9
Hyperoxia increases H2O2 release by lung mitochondria and microsomes.
Arch Biochem Biophys. 1982 Sep;217(2):411-21. doi: 10.1016/0003-9861(82)90519-7.
10
Determination of hemoglobin and its derivatives.
Adv Clin Chem. 1965;8:141-87. doi: 10.1016/s0065-2423(08)60414-x.
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