呼气戊烷作为早产儿脂质过氧化和不良结局的标志物。
Breath pentane as a marker for lipid peroxidation and adverse outcome in preterm infants.
作者信息
Nycyk J A, Drury J A, Cooke R W
机构信息
Department of Child Health, Liverpool Women's Hospital.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1998 Jul;79(1):F67-9. doi: 10.1136/fn.79.1.f67.
Abstract
AIM
To test the hypothesis that complications of neonatal intensive care are related to increased oxygen derived free radical activity, using breath pentane as a marker of lipid peroxidation.
METHODS
Exhaled breath was collected daily from 57 ventilated preterm infants and pentane concentration measured by gas chromatography.
RESULTS
High peak pentane exhalation was significantly associated with low gestational age, mortality, intraventricular haemorrhage and retinopathy of prematurity. Peak pentane was not significantly associated with the development of chronic lung disease.
CONCLUSIONS
The demonstration that pentane exhalation is related to the course of neonatal disease and its outcome is consistent with the hypothesis that lipid peroxidation is associated with these illnesses, and may contribute to their severity. If this is a causal relation, antioxidant treatments could prove useful in reducing their severity. Measurement of breath pentane might assist in the assessment of antioxidant strategies prior to more extensive clinical trials.
摘要
目的
以呼出戊烷作为脂质过氧化的标志物，验证新生儿重症监护并发症与氧衍生自由基活性增加相关这一假说。
方法
每日收集57例接受机械通气的早产儿的呼出气，采用气相色谱法测定戊烷浓度。
结果
呼出戊烷峰值高与胎龄小、死亡率、脑室内出血及早产儿视网膜病变显著相关。戊烷峰值与慢性肺病的发生无显著关联。
结论
呼出戊烷与新生儿疾病病程及其转归相关，这一结果与脂质过氧化与这些疾病相关的假说一致，且可能导致疾病严重程度增加。如果这是一种因果关系，抗氧化治疗可能有助于减轻疾病严重程度。在开展更广泛的临床试验之前，测定呼出气戊烷可能有助于评估抗氧化策略。
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