Idel H, Bunke R, Seemayer N
Zentralbl Bakteriol B. 1978 Sep;167(3):253-61.
We report about the occurrence and importance of antinuclear antibodies in patients with malignant diseases. - We analyzed 110 sera of patients with tumors and found in 42% ANA. In contrast a corresponding control group contained ANA in 1.8%. - Patients with bronchogenic carcinoma and those of the digestive tract possessed ANA in a comparable percentage of 36 and 39, respectively. - Sera of patients with mamma- and uteruscarcinoma contained ANA in nearly 50%. - A connection between the type of the tumor and occurrence of ANA can be assumed. - Antibodies were directed against different antigens of the nucleus, often simultaneously occurring. Antibodies which we have detected, belong to different classes of immunoglobulins (IgG, IgM and IgA). In most cases we found a combination of antibodies. In 51% of positive cases antibodies were able to fix complement.
我们报告了恶性疾病患者中抗核抗体的出现情况及其重要性。- 我们分析了110例肿瘤患者的血清，发现42%的患者存在抗核抗体。相比之下，相应的对照组中抗核抗体的比例为1.8%。- 支气管癌患者和消化道癌患者中抗核抗体的比例分别为36%和39%，相当接近。- 乳腺癌和子宫癌患者的血清中抗核抗体含量近50%。- 可以推测肿瘤类型与抗核抗体的出现之间存在关联。- 抗体针对细胞核的不同抗原，且常同时出现。我们检测到的抗体属于不同类别的免疫球蛋白（IgG、IgM和IgA）。在大多数情况下，我们发现抗体是组合存在的。在51%的阳性病例中，抗体能够固定补体。
