类风湿关节炎患者补体系统与血脂谱的关系。

Relationship between the complement system and serum lipid profile in patients with rheumatoid arthritis.

机构信息

Division of Central Laboratory, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.

Division of Rheumatology , Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.

出版信息

Front Immunol. 2024 Jul 12;15:1420292. doi: 10.3389/fimmu.2024.1420292. eCollection 2024.

DOI:10.3389/fimmu.2024.1420292

PMID:39072319

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11272461/

Abstract

BACKGROUND

The complement system has been linked to the etiopathogenesis of rheumatoid arthritis (RA). Patients with RA exhibit a dysregulated profile of lipid molecules, which has been attributed to the inflammation present in the disease. In this study, we aimed to evaluate the association between a comprehensive assessment of the complement system and the lipid profile of patients with RA.

METHODS

430 patients with RA were recruited. New-generation techniques were employed to conduct functional assays of the three pathways of the complement system. Serum levels of various complement components such as C1q, factor D, properdin, lectin, C1-inhibitor, C2, C4, C4b, C3, C3a, C5, C5a, and C9 were assessed. Furthermore, a complete pattern of lipid molecules was measured including high (HDL), low-density lipoproteins (LDL), and lipoprotein (a). Multivariable linear regression analysis was conducted to investigate the association between the complement system and lipid profile in RA patients.

RESULTS

After multivariable analysis, several noteworthy associations emerged between the complement system and lipid molecules. Notably, complement components most strongly linked to the lipid profile were C1q and properdin, representing the upstream classical and alternative pathways, along with C3 from the common cascade. These associations demonstrated significance and positivity concerning total cholesterol, LDL, atherogenic index, apolipoprotein B, and lipoprotein(a), suggesting a connection with an unfavorable lipid profile. Interestingly, complement functional assays of the three pathways and activated products such as C3a and C5a showed no correlation with the lipid pattern.

CONCLUSION

The correlation between the complement system and lipid molecule patterns is pronounced in patients with RA. This relationship is predominantly positive and primarily associated with upstream complement components rather than activated ones.

摘要

背景

补体系统与类风湿关节炎（RA）的发病机制有关。RA 患者表现出脂质分子的失调谱，这归因于疾病中的炎症。在这项研究中，我们旨在评估补体系统的综合评估与 RA 患者脂质谱之间的关联。

方法

招募了 430 名 RA 患者。采用新一代技术对补体系统的三个途径进行功能测定。评估了各种补体成分（如 C1q、因子 D、备解素、凝集素、C1 抑制剂、C2、C4、C4b、C3、C3a、C5、C5a 和 C9）的血清水平。此外，还测量了完整的脂质分子模式，包括高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和脂蛋白（a）。进行多变量线性回归分析以研究 RA 患者补体系统与脂质谱之间的关联。

结果

经过多变量分析，补体系统与脂质分子之间存在一些值得注意的关联。值得注意的是，与脂质谱最密切相关的补体成分是 C1q 和备解素，代表上游经典和替代途径，以及共同级联中的 C3。这些关联在总胆固醇、LDL、致动脉粥样硬化指数、载脂蛋白 B 和脂蛋白（a）方面具有重要意义和阳性意义，表明与不利的脂质谱有关。有趣的是，补体三个途径的功能测定和激活产物（如 C3a 和 C5a）与脂质模式没有相关性。