Leverve X M
Laboratoire de Bioénergétique Fondamentale et Appliquée, Université Joseph Fourier, Grenoble, France.
Curr Opin Clin Nutr Metab Care. 1999 Mar;2(2):165-9. doi: 10.1097/00075197-199903000-00013.
The potential role of an energy defect in acute diseases is still in the centre of the pathophysiological understanding of such states and therefore of our attempts to limit or to reverse the possible deleterious consequences of such defect. In fact several recent experimental works have shown that instead of being a negative consequence, the lactate production and the related metabolic acidosis due to the stimulation of anaerobic ATP-production pathway is rather a protective adapted response.
能量缺陷在急性疾病中的潜在作用仍然是对这些状态进行病理生理理解的核心，因此也是我们试图限制或逆转这种缺陷可能产生的有害后果的核心。事实上，最近的几项实验研究表明，由于无氧ATP产生途径的刺激而导致的乳酸生成和相关代谢性酸中毒并非负面后果，而是一种适应性保护反应。
