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[溶解臭氧对不同结核分枝杆菌菌株的体外杀菌作用]

[In vitro bactericidal action of dissolved ozone on different strains of Mycobacterium tuberculosis].

作者信息

Belianin I I, Safonova S G

出版信息

Probl Tuberk. 1999(2):48-9.

PMID:10454899
Abstract

The mycobacterium tuberculosis (MBT) strains H37 Rv (USA and Czechoslovakia), Erdman, and multiresistant clinical strain 2255 having different milliliter levels of microbes were kept in the soluble ozone at the concentrations of 1-4 micrograms/ml for 30 and 60 minutes. The soluble ozone-treated strains were cultured in the Finn-I medium. The soluble ozone at the concentration was found to produce bactericidal and bacteriostatic effects on MBT, including multiresistant strains. The MBT strains resistant to antituberculosis agents were also more resistant to soluble ozone; however, longer exposure to the "therapeutical" concentrations of soluble ozone proved to damage multiresistant strains.

摘要

结核分枝杆菌(MBT)菌株H37 Rv(美国和捷克斯洛伐克)、埃尔德曼菌株以及具有不同微生物毫升水平的多重耐药临床菌株2255,在浓度为1 - 4微克/毫升的可溶性臭氧中分别保存30分钟和60分钟。经可溶性臭氧处理的菌株在芬兰-I培养基中培养。发现该浓度的可溶性臭氧对MBT包括多重耐药菌株产生杀菌和抑菌作用。对抗结核药物耐药的MBT菌株对可溶性臭氧也更具耐药性;然而,长时间暴露于“治疗”浓度的可溶性臭氧被证明会损害多重耐药菌株。

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