Belianin I I, Nikolaeva G M, Martynova L P
Central NII of Tuberculosis RAMN, Moscow.
Probl Tuberk. 1997(1):56-9.
Sixty CBA mice were intravenously inoculated with the Mycobacterium tuberculosis (MBT) strains Erdman and 2255 (a polyresistant clinical strain) pretreated with dissolved ozone (experimental groups), a single therapeutical dose. of dissolved ozone being intravenously injected. By 1 month of inoculation, all control mice (MBT-inoculated and ozone-untreated) died and in their organs there were a great deal of MBT both outside and inside the macrophages. No pathogen in its typical form was not found in experimental mice, but there were many granular and L forms, the lung showing a large number of highly vacuolized (foamy) alveolar macrophages (AM). All experimental mice survived by month 5 and their organ examination showed that the pathogen was detectable only inside the macrophages, but they are chiefly unchanged (more elongated and badly stained with aniline dyes). Juvenile forms are prevalent among AM. It should be concluded that the action of dissolved ozone on AM and MBT is heterodirectional.
60只CBA小鼠通过静脉注射接种了用溶解臭氧预处理过的结核分枝杆菌（MBT）菌株埃尔德曼和2255（一种多重耐药临床菌株）（实验组），静脉注射单一治疗剂量的溶解臭氧。接种1个月后，所有对照小鼠（接种MBT但未用臭氧处理）死亡，其器官内巨噬细胞内外均有大量MBT。在实验小鼠中未发现典型形态的病原体，但有许多颗粒状和L型，肺中显示出大量高度空泡化（泡沫状）的肺泡巨噬细胞（AM）。所有实验小鼠在第5个月时存活，对其器官的检查表明，仅在巨噬细胞内可检测到病原体，但它们主要未发生变化（更细长且苯胺染料染色不佳）。幼年形式在AM中占主导。可以得出结论，溶解臭氧对AM和MBT的作用是异向的。
